Reaction #433604

Reaction equation

3-Bromoaniline

4-chloro-6-nitroquinazoline

→

4-[(3-bromophenyl)amino]-6-nitroquinazoline

Yield 95.4%

Solvents

iso-propylalcohol

Conditions

Procedure

3-Bromoaniline (1.72 grams, 10 mmol) was reacted with 4-chloro-6-nitroquinazoline (523 mg, 2.5 mmol), in iso-propylalcohol, as is described hereinabove, to give 4-[(3-bromophenyl)amino]-6-nitroquinazoline (823 mg, 95% yield), which was thereafter reacted (590 mg, 1.7 mmol) with hydrazine hydrate, according to the procedure described hereinabove, to give 4-[(3-bromophenyl)amino]-6-aminoquinazoline (332 mg, 62% yield).

Source