Reaction #433600
ord-52aec6f9f1334395bc181d147ce3e3db
Reaction equation
4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline
hydrazine hydrate
→
6-amino-4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline
Yield 75.0%
Reactants
Reagents
Conditions
Detailed conditions
See reaction.notes.procedure_details.
Procedure
4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]-6-nitroquinazoline was reacted with hydrazine hydrate and Raney®Nickel, as described hereinabove, to produce 6-amino-4-[(3,4-dichloro-6-fluorophenyl)amino]-7-[3-(4-morpholinyl)propoxy]quinazoline in 75% yield.