Reaction #4333

Reaction equation

4,5-dichloro-2-nitroaniline

ethanolamine

→

2-amino-4-β-hydroxyethylamino-5-chloronitrobenzene

Solvents

dioxane

dioxane

Conditions

Workup

1. 1
   TemperatureThe reaction mixture is heated for 6 hours
2. 2
   OtherAfter dilution with water and neutralization with concentrated hydrochloric acid, the expected product precipitates

Procedure

0.11 mole (22.8 g) of 4,5-dichloro-2-nitroaniline is added to a solution of 0.55 mole (33.3 ml) of ethanolamine in 70 ml of dioxane. The reaction mixture is heated for 6 hours in refluxing dioxane. After dilution with water and neutralization with concentrated hydrochloric acid, the expected product precipitates.

Source