Reaction #42824

Reaction equation

ammonium chloride

4-(2-butynyloxy)-6-chloropyrimidine

potassium carbonate

3,3,5,5-tetramethylpiperidine hydrochloride

→

4-(2-butynyloxy)-6-(3,3,5,5-tetramethylpiperidino)pyrimidine

Yield 73.1%

Solvents

acetonitrile

Conditions

Workup

1. 1
   TemperatureThe reaction mixture was cooled to near room temperature
2. 2
   Extractionthe mixture was extracted with tert-butyl methyl ether three times
3. 3
   WashThe organic layers were washed with a saturated sodium chloride aqueous solution
4. 4
   Dryingdried over anhydrous magnesium sulfate
5. 5
   Concentrationconcentrated

Procedure

Into 2 ml of acetonitrile were added 0.20 g of 4-(2-butynyloxy)-6-chloropyrimidine, 0.45 g of potassium carbonate and 0.24 g of 3,3,5,5-tetramethylpiperidine hydrochloride, and the mixture was stirred for 4 hours at 60° C. The reaction mixture was cooled to near room temperature, a saturated ammonium chloride aqueous solution was added therein, and the mixture was extracted with tert-butyl methyl ether three times. The organic layers were washed with a saturated sodium chloride aqueous solution, dried over anhydrous magnesium sulfate and concentrated. The residue was subjected to silica gel column chromatography to obtain 0.23 g of 4-(2-butynyloxy)-6-(3,3,5,5-tetramethylpiperidino)pyrimidine (hereinafter, referred to as Compound (38)).

Source