Reaction #42601

Reaction equation

(3-oxo-4-propyl-cyclohexyl)-acetic acid

2-(3-oxo-cyclohexyl)-malonic acid diethyl ester

→

(3-Oxo-cyclohexyl)-acetic acid

Yield 70.0%

Conditions

Procedure

Step 2 (3-Oxo-cyclohexyl)-acetic acid was prepared in 70% yield from 2-(3-oxo-cyclohexyl)-malonic acid diethyl ester by the method described above for the synthesis of (3-oxo-4-propyl-cyclohexyl)-acetic acid: 1H NMR (300 MHz, CDCl3) δ 2.58-1.92 (m, 7H), 1.80-1.61 (m, 1H), 1.52-1.42 (m, 1H); ESI MS m/z 155 [M−H]−.

Source