Reaction #42121

Reaction equation

product

4-amino-3-chloro-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-isobutyl-1,8-naphthyridin-2(1H)-one

N,N-dimethylformamide dimethylacetal

→

title compound

N′-[3-chloro-6-(4-chlorophenyl)-7-(2,4-dichlorophenyl)-1-isobutyl-2-oxo-1,2-dihydro-1,8-naphthyridin-4-yl]-N,N-dimethylimidoformamide

Conditions

Workup

1. 1
   Concentrationwas concentrated in vacuo
2. 2
   OtherPurification by flash chromatography on silica
3. 3
   Washeluted with 0-30% EtOAc in hexane

Procedure

The product of EXAMPLE 61 (50 mg) was combined with N,N-dimethylformamide dimethylacetal (4 mL). The reaction was heated to 95° C. and stirred for 90 minutes at which the solution was concentrated in vacuo. Purification by flash chromatography on silica eluted with 0-30% EtOAc in hexane afforded the title compound (E/Z mixture of isomers). HPLC/MS: 560.9 (M+1), 562.9 (M+3); Rt=4.48 min.

Source