Reaction #42066

Reaction equation

4-methyl-3-[6-(3-pyridyl)pyrimidin-4-ylamino]aniline

4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride

→

4-(1-methylpiperazin-4-ylmethyl)-3-trifluoromethyl-N-{4-methyl-3-[6-(3-pyridyl)pyrimidin-4-ylamino]phenyl}benzamide

Conditions

Workup

1. 1
   Washthe resulting crude crystals were washed with ethyl acetate

Procedure

This compound was prepared in the same manner as in Example 1, except that 4-methyl-3-[6-(3-pyridyl)pyrimidin-4-ylamino]aniline (Reference Example 20) and 4-(4-methylpiperazin-1-ylmethyl)-3-trifluoromethylbenzoyl chloride dihydrochloride (Reference Example 2) were used, and that the reaction was conducted at room temperature for 92 hours and the resulting crude crystals were washed with ethyl acetate.

Source