Reaction #41840

Reaction equation

4-(4-cyclopropyl-piperazine-1-carbonyl)-benzaldehyde

acetonitrile

NaHSO3

→

Sodium [4-(4-Cyclopropyl-piperazine-1-carbonyl)-phenyl]-hydroxy-methanesulfonate

Solvents

water

water

Conditions

Workup

1. 1
   TemperatureThe reaction mixture was then cooled to 17° C
2. 2
   FiltrationThe product was collected by filtration as a white solid

Procedure

A 100 mL flask was charged with 4-(4-cyclopropyl-piperazine-1-carbonyl)-benzaldehyde (2.58 g, 10.0 mmol, 1.0 eq), acetonitrile (30 mL), and water (1.0 mL) under nitrogen atmosphere. The reaction mixture was heated to 50° C. A solution of NaHSO3 (1.14 g, 11.0 mol, 1.1 eq) in water (2.0 mL) was added dropwise over 5 min. The reaction mixture was then cooled to 17° C. The product was collected by filtration as a white solid.

Source