Reaction #41819

Reaction equation

(4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone, dihydrochloride

H2O

MTBE

→

title compound

(4-Isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone, dihydrochloride monohydrate

Solvents

EtOH

Conditions

Workup

1. 1
   TemperatureThe resulting solution was cooled to room temperature
2. 2
   TemperatureThe resulting suspension was cooled to 0° C.
3. 3
   Filtrationfiltered
4. 4
   WashThe filter cake was washed with MeOH (15 mL)
5. 5
   OtherThe solids were dried in a vacuum oven at 105° C. for 20 h

Procedure

A suspension of crude (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone, dihydrochloride (2.1 g, 5.2 mmol) in absolute EtOH (30 mL) was heated to 78° C. and H2O (2.2 mL) was added. The resulting solution was cooled to room temperature and MTBE (5 mL) was added. The resulting suspension was cooled to 0° C. and filtered. The filter cake was washed with MeOH (15 mL). The solids were dried in a vacuum oven at 105° C. for 20 h to yield the title compound as a white solid.

Source