Reaction #41818

Reaction equation

MTBE

(4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl -phenyl)-methanone

HCl

→

crude title compound

(4-Isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl-phenyl)-methanone, dihydrochloride monohydrate

Solvents

EtOH

Conditions

Workup

1. 1
   Filtrationfiltered
2. 2
   WashThe filter cake was washed with MTBE (20 mL)
3. 3
   Otherthe solid was dried in a vacuum oven at 60° C. for 20 h

Procedure

A solution of (4-isopropyl-piperazin-1-yl)-(4-morpholin-4-ylmethyl -phenyl)-methanone (2.0 g, 6.0 mmol) in absolute EtOH (20 mL) was treated with HCl(g) (0.5 g, 13.7 mmol) at room temperature. The resulting suspension was stirred for 1 h, and then MTBE (5 mL) was added. The suspension was cooled to 0° C. and filtered. The filter cake was washed with MTBE (20 mL), and the solid was dried in a vacuum oven at 60° C. for 20 h to yield crude title compound as a white solid.

Source