Reaction #41809

Reaction equation

Hydrazine monohydrate

phthalimide

2-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine

→

diamine

3-Fluoro-4-(4-methyl-piperazin-1-yl)-benzene-1,2-diamine

Solvents

ethanol

Conditions

Workup

1. 1
   Filtrationwas filtered through Celite
2. 2
   WashThe filter cake was rinse with EtOAc (3×)
3. 3
   Concentrationconcentrated

Procedure

Hydrazine monohydrate (0.13 mL, 2.7 mmol) was added to a solution of phthalimide 1 (134 mg, 0.39 mmol) in ethanol (4 mL). The reaction was maintained overnight at rt and then was filtered through Celite. The filter cake was rinse with EtOAc (3×) and the organic portions were combined and concentrated to give diamine 2 which was carried forward without further purification: LCMS m/z 215.1 (MH+), tR=1.77 min.

Source