Reaction #41798

Reaction equation

N-methylpiperazine

NMP

triethylamine

5-fluoro-2-nitrophenylamine

→

5-(4-Methyl-piperazin-1-yl)-2-nitro-phenylamine

Solvents

water

Conditions

Workup

1. 1
   OtherThe resulting solid was collected
2. 2
   Otherdried
3. 3
   Otherutilized without further purification

Procedure

A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5-fluoro-2-nitrophenylamine (1.0 eq) were heated at 90° C. for 1 hours. The reaction was allowed to cool to room temperature and then poured into water and let stand for 12 hours. The resulting solid was collected and dried and utilized without further purification. MH+=237.3.

Source