Reaction #41797

Reaction equation

N-methylpiperazine

NMP

triethylamine

5,6-difluoro-2-nitroaniline

→

2-Fluoro-3-(4-methyl-piperazin-1-yl)-6-nitro-phenylamine

Solvents

water

Conditions

Workup

1. 1
   OtherThe resulting solid was collected
2. 2
   Otherdried
3. 3
   Otherutilized without further purification

Procedure

A solution of N-methylpiperazine (1.0 eq), NMP, triethylamine (3.0 eq) and 5,6-difluoro-2-nitroaniline (1.0 eq) were heated at 90° C. for 1 hour. The reaction was allowed to cool to room temperature and then poured into water and let stand for 1 hour. The resulting solid was collected and dried and utilized without further purification. MH+=255.3

Source