Reaction #417951

Reaction equation

4-bromo-5-fluoro-pyridin-2-ol

ethyliodide

→

4-Bromo-2-ethoxy-5-fluoro-pyridine

Solvents

DCM

Conditions

Workup

1. 1
   OtherThe reaction is quenched by the addition of water
2. 2
   workup.ADDITIONDCM is added
3. 3
   Filtrationthe resulting mixture is filtered
4. 4
   Dryingdried over MgSO4
5. 5
   Filtrationfiltered again
6. 6
   Otherthe solvent is removed in vacuo

Procedure

0.20 g (1.04 mmol) 4-bromo-5-fluoro-pyridin-2-ol, 0.83 mL (10.4 mmol) ethyliodide and 0.43 g (1.56 mmol) Ag2CO3 are added to 5 mL DCM and stirred at r.t. over night. The reaction is quenched by the addition of water. DCM is added, the resulting mixture is filtered and the organic layer is separted, dried over MgSO4, filtered again and the solvent is removed in vacuo.

Source