Reaction #417934

ord-653a29921ad541cd957e9893431a59c5

Reaction equation

Oc1ccccc1
phenol
Cc1ccccc1CCC(=O)Cl
3-o-tolylpropanoyl chloride
→
Cc1ccccc1CCC(=O)Oc1ccccc1
product
Yield 93.0%
Cc1ccccc1CCC(=O)Oc1ccccc1
Phenyl 3-(o-tolyl)propanoate
Yield 93.0%

Reactants

Oc1ccccc1
phenol
Cc1ccccc1CCC(=O)Cl
3-o-tolylpropanoyl chloride
—
crude product

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    workup.DISTILLATIONdistilled at 127-129° C./0.05 mbar

Procedure

The procedure as described in Example 4a) was repeated with phenol (48 mmol) and 3-o-tolylpropanoyl chloride (55 mmol). The crude product (12.4 g, 97%) was short path distilled at 127-129° C./0.05 mbar to yield 10.6 g (93%) of product as a colourless, semicrystalline oil.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08877704B2uspto-grants-2014_11