Reaction #41731

Reaction equation

hydrochloric acid

2-amino-4-methoxyphenol

O-ethylxanthic acid

potassium

→

5-methoxybenzoxazole-2-thiol

Solvents

pyridine

Conditions

Workup

1. 1
   Temperaturewas refluxed for two hours

Procedure

The mixture containing 2-amino-4-methoxyphenol (1 eq) and O-ethylxanthic acid, potassium salt (1.1 eq) in pyridine was refluxed for two hours. The resultant mixture was poured in to ice/water containing hydrochloric acid to yield a 5-methoxybenzoxazole-2-thiol as a tan solid. MS: MH+=182

Source