Reaction #41730

ord-9859e4cb3c784b4dacad0dfeee6473d1

Reaction equation

COc1ccc(O)c([N+](=O)[O-])c1
4-methoxy-2-nitrophenol
→
COc1ccc(O)c(N)c1
2-amino-4-methoxyphenol

Reactants

COc1ccc(O)c([N+](=O)[O-])c1
4-methoxy-2-nitrophenol

Reagents

[Pd]
Pd/C

Solvents

CO
methanol

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The mixture containing 4-methoxy-2-nitrophenol in methanol with catalytic amount of 10% Pd/C was hydrogenated until disappearance of yellow color to yield 2-amino-4-methoxyphenol. MS: MH+=140.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07728010B2uspto-grants-2010_06