Reaction #41665

ord-07de9e32f5b2442db95aef7c86370ae0

Reaction equation

CS(=O)(=O)c1ccc(O)cc1
4-(methanesulfonyl)phenol
CC(=O)OC1CCN(C(C)=O)C1c1cc([N+](=O)[O-])c(NC(=O)c2ccccn2)cc1F
1-acetyl-2-(2-fluoro-5-nitro-4-((pyridin-2-ylcarbonyl)amino)phenyl)pyrrolidin-3-yl acetate
→
CC(=O)OC1CCN(C(C)=O)C1c1cc2[nH]c(-c3ccccn3)nc2cc1Oc1ccc(S(C)(=O)=O)cc1
1-acetyl-2-(5-(4-(methanesulfonyl)phenoxy)-2-pyridin-2-yl-1H-benzimidazol-6-yl)pyrrolidin-3-yl acetate

Reactants

CS(=O)(=O)c1ccc(O)cc1
4-(methanesulfonyl)phenol
CC(=O)OC1CCN(C(C)=O)C1c1cc([N+](=O)[O-])c(NC(=O)c2ccccn2)cc1F
1-acetyl-2-(2-fluoro-5-nitro-4-((pyridin-2-ylcarbonyl)amino)phenyl)pyrrolidin-3-yl acetate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThe entitled compound was obtained as a white solid in the same method as in Example 338 (step 5) or in accordance with the method

Procedure

The entitled compound was obtained as a white solid in the same method as in Example 338 (step 5) or in accordance with the method or by combining it with an ordinary method but using 4-(methanesulfonyl)phenol and (1-acetyl-2-(2-fluoro-5-nitro-4-((pyridin-2-ylcarbonyl)amino)phenyl)pyrrolidin-3-yl acetate diastereomer A.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07728025B2uspto-grants-2010_06