Reaction #413999

Reaction equation

1-(3-trifluoromethylbenzoyl)-1-methanesulfonyl-2-(N,N-dimethylamino)ethene

2,4-difluorobenzamidine hydrochloride

sodium methoxide

→

2-(2,4-difluorophenyl)-4-(3-trifluoromethylphenyl)-5-methanesulfonylpyrimidine

Yield 77.5%

Solvents

methanol

Conditions

Workup

1. 1
   TemperatureThe resulting mixture was heated
2. 2
   Temperatureunder reflux for an hour
3. 3
   workup.DISTILLATIONThe solvent was distilled away under reduced pressure
4. 4
   WashThe residue was washed with water
5. 5
   Otherdried

Procedure

6 g of 1-(3-trifluoromethylbenzoyl)-1-methanesulfonyl-2-(N,N-dimethylamino)ethene and 4.6 g of 2,4-difluorobenzamidine hydrochloride were dissolved in 30 ml of methanol at room temperature and 1.2 g of sodium methoxide was added thereto. The resulting mixture was heated under reflux for an hour. The solvent was distilled away under reduced pressure. The residue was washed with water and then dried to obtain 6 g of 2-(2,4-difluorophenyl)-4-(3-trifluoromethylphenyl)-5-methanesulfonylpyrimidine (Compound 147).

Source