Reaction #41360

ord-d88dcb7044d84a3aa2d39f3c002292de

Reaction equation

CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C
(S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
[Cl][Mg][CH2]c1ccccc1
benzylmagnesium chloride
→
C[C@H](NC(=O)OC(C)(C)C)C(=O)Cc1ccccc1
tert-Butyl N-[(2S)-3-oxo-4-phenyl-butan-2-yl]carbamate

Reactants

CON(C)C(=O)[C@H](C)NC(=O)OC(C)(C)C
(S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate
[Cl][Mg][CH2]c1ccccc1
benzylmagnesium chloride

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherPrepared

Procedure

Prepared as described in Example 6 from (S)-tert-butyl 1-(methoxy(methyl)amino)-1-oxopropan-2-ylcarbamate (600 mg, 2.58 mmol) and benzylmagnesium chloride (2.0 M in THF, 3.87 mL, 7.75 mmol). Yield 653 mg (96%).

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07728030B2uspto-grants-2010_06