Reaction #41156

Reaction equation

Cyclohexylhydrazine hydrochloride

ethyl (ethoxymethylene)-cyanoacetate

sodium acetate

→

5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester

Yield 92.9%

Solvents

ethanol

Conditions

Workup

1. 1
   Temperaturethen cooled to room temperature
2. 2
   Concentrationconcentrated
3. 3
   OtherThe residue was partitioned between methylene chloride and water
4. 4
   ExtractionThe separated aqueous phase was extracted with a second portion of methylene chloride
5. 5
   WashThe organic phases were successively washed with water and brine
6. 6
   Dryingdried over sodium sulfate
7. 7
   Concentrationconcentrated in vacuo
8. 8
   OtherThe residue was purified by flash chromatography
9. 9
   Washeluting with a gradient of 25-70% ethyl acetate/hexanes

Procedure

Cyclohexylhydrazine hydrochloride (3.057 g, 20.29 mmol, CAS #24214-73-1, purchased from Aldrich) was combined with ethyl (ethoxymethylene)-cyanoacetate (3.390 g, 20.04 mmol) and anhydrous sodium acetate (2.080 g, 25.36 mmol) in 30 mL ethanol. The mixture was heated at 70° C. for 16 hours then cooled to room temperature and concentrated. The residue was partitioned between methylene chloride and water. The separated aqueous phase was extracted with a second portion of methylene chloride. The organic phases were successively washed with water and brine and then combined, dried over sodium sulfate and concentrated in vacuo. The residue was purified by flash chromatography eluting with a gradient of 25-70% ethyl acetate/hexanes to give 5-amino-1-cyclohexyl-1H-pyrazole-4-carboxylic acid ethyl ester (4.42 g, 92%). Mass spectrum: m/z: 238.1 (M+H).

Source