Reaction #40970

Reaction equation

Water

5-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione

K2CO3

3-bromo-1,1dimethoxy-propane

→

final compound

Yield 53.0%

1-(3,3-Dimethoxy-propyl)-5-(2,4-dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione

Yield 53.0%

Solvents

DMF

DMF

Conditions

Workup

1. 1
   workup.STIRRINGthe mixture stirred at room temperature for 72 hours
2. 2
   Extractionthe product extracted with ethyl acetate
3. 3
   DryingThe organic phase was dried (Na2SO4)
4. 4
   Otherevaporated

Procedure

5-(2,4-Dimethyl-oxazol-5-yl)-1H-pyrimidine-2,4-dione (Prep62, 480 mg, 2.32 mmol) and K2CO3 (320 mg, 2.32 mmol) were suspended in dry DMF (6 ml) and stirred at room temperature for 1 h. A solution of 3-bromo-1,1dimethoxy-propane (467 mg, 2.55 mmol) in dry DMF (2 mL) was added dropwise and the mixture stirred at room temperature for 72 hours. Water (80 mL) was added and the product extracted with ethyl acetate. The organic phase was dried (Na2SO4) and evaporated to give 377 mg of the final compound that was used without any other purification in the next step (53% yield).

Source