Reaction #40951

Reaction equation

Water

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione

K2CO3

bromo-chloro-propane

→

title compound

Yield 98.1%

3-Benzoyl-1-(3-chloro-propyl)-5-iodo-1H-pyrimidine-2,4-dione

Yield 98.1%

Solvents

DMF

Conditions

Workup

1. 1
   workup.STIRRINGthe mixture stirred at room temperature overnight
2. 2
   Extractionthe mixture was extracted with ethyl acetate
3. 3
   DryingThe organic phase was dried (Na2SO4)
4. 4
   Filtrationfiltered
5. 5
   Otherevaporated

Procedure

3-Benzoyl-5-iodo-1H-pyrimidine-2,4-dione (Prep36, 3 g, 8.77 mmol) and K2CO3 (1.2 g, 8.77 mmol) were suspended in dry DMF (45 mL) and stirred at room temperature for 1 h. Then, bromo-chloro-propane (2.7 mL, 17.5 mmol) was added dropwise and the mixture stirred at room temperature overnight. Water was added and the mixture was extracted with ethyl acetate. The organic phase was dried (Na2SO4), filtered and evaporated to give the title compound as a pale yellow oil (3.6 g, 98% yield).

Source