Reaction #40710

Reaction equation

4-morpholinoacetophenone

N,N-dimethylformamide dimethyl acetal

hydrazine hydrate

→

title compound

4-[4-(1H-Pyrazol-3-yl)phenyl]morpholine

Solvents

methanol

Conditions

Workup

1. 1
   Temperaturewas heated
2. 2
   Temperatureunder reflux for 7 hours
3. 3
   Temperatureagain heated
4. 4
   Temperatureunder reflux for about 6 hours
5. 5
   OtherThe solid formed
6. 6
   Temperatureon cooling the mixture
7. 7
   Filtrationwas filtered off with suction
8. 8
   Washthoroughly washed with methanol

Procedure

A mixture of 2.05 g of 4-morpholinoacetophenone (10 mmol) and N,N-dimethylformamide dimethyl acetal was heated under reflux for 7 hours. The mixture was then mixed with 30 ml of methanol and, after addition of 0.57 ml of hydrazine hydrate, again heated under reflux for about 6 hours. The solid formed on cooling the mixture was filtered off with suction and thoroughly washed with methanol, resulting in 3.8 g of the title compound.

Source