Reaction #40461

ord-a246859ab003474d815d88040d024039

Reaction equation

CCOc1c(Cl)cc2c([nH]c3cnccc32)c1N
6-chloro-7-ethoxy-9H-β-carbolin-8-ylamine
Cc1ncccc1C(=O)O
2-methylnicotinic acid
→
CCOc1c(Cl)cc2c([nH]c3cnccc32)c1NC(=O)c1cccnc1C
desired compound
Yield 40.0%
CCOc1c(Cl)cc2c([nH]c3cnccc32)c1NC(=O)c1cccnc1C
N-(6-chloro-7-ethoxy-9H-β-carbolin-8-yl)-2-methyl-nicotinamide
Yield 40.0%

Reactants

CCOc1c(Cl)cc2c([nH]c3cnccc32)c1N
6-chloro-7-ethoxy-9H-β-carbolin-8-ylamine
Cc1ncccc1C(=O)O
2-methylnicotinic acid

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The desired compound was prepared according to Method A from 6-chloro-7-ethoxy-9H-β-carbolin-8-ylamine and 2-methylnicotinic acid in 40% yield.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07727985B2uspto-grants-2010_06