Reaction #40287

ord-128be03e30fc479198b6496eaff8785b

Reaction equation

CCOC(=O)CON
2-Aminoxy-acetic acid ethyl ester
C#CCCC(=O)O
4-Pentynoic acid
C(=NC1CCCCC1)=NC1CCCCC1
dicyclohexylcarbodiimide
→
C#CCCC(=O)NOCC(=O)OCC
Pent-4-ynoylaminooxy-acetic Acid Ethyl Ester

Reactants

CCOC(=O)CON
2-Aminoxy-acetic acid ethyl ester
C#CCCC(=O)O
4-Pentynoic acid
C(=NC1CCCCC1)=NC1CCCCC1
dicyclohexylcarbodiimide

Reagents

None

Solvents

CCOC(C)=O
EtOAc

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

To a solution of 2-Aminoxy-acetic acid ethyl ester (573 mg, 4.8 mmol) and 4-Pentynoic acid (441 mg, 4.5 mmol) in 15 mL EtOAc were added dicyclohexylcarbodiimide (928 mg, 4.5 mmol) and the resulting mixture was stirred at room temperature for 16 h.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07727713B2uspto-grants-2010_06