Reaction #3945

Reaction equation

2-(2-methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one

hydrogen peroxide

→

2-(2-Methoxy-4-methylsulfinyl-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one

Solvents

acetic acid

Conditions

Workup

1. 1
   workup.STIRRINGIt is then stirred until a precipitate
2. 2
   Otherhas formed
3. 3
   FiltrationThis is subjected to suction filtration
4. 4
   Otherpurified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:3)]

Procedure

An amount of 0.21 gm of 2-(2-methoxy-4-methylmercapto-phenyl)-5H-imidazo[4,5-d]pyridazin-4-one is suspended in 10 ml of glacial acetic acid and mixed with 0.08 ml of 30% hydrogen peroxide. The mixture is stirred for 24 hours at ambient temperature and poured onto 20 ml of ice water. It is then stirred until a precipitate has formed. This is subjected to suction filtration and purified by chromatography on silica gel [eluant: methylene chloride/ethanol (100:0 to 100:3)].

Source