Reaction #3742

ord-db920a7cf3b74cdbbcd3ab9ee72edff5

Reaction equation

N#Cc1nccnc1C#N
2, 3-dicyano-pyrazine
C=C(C)C
isobutylene
O=S(=O)(O)O
sulfuric acid
→
CC(C)(C)NC(=O)c1cnccn1
N-tert-butyl-2-pyrazinecarboxamide
CC(C)(C)NC(=O)c1nccnc1C#N
3-cyano-N-tert-butyl-2-pyrazinecarboxamide

Reactants

N#Cc1nccnc1C#N
2, 3-dicyano-pyrazine
C=C(C)C
isobutylene
O=S(=O)(O)O
sulfuric acid
—
( 4 )

Reagents

None

Solvents

CC(C)(C)O
tert-butyl alcohol

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    Othercan be obtained

Procedure

A compound having the formula (4) can be obtained as follows. The corresponding 2, 3-dicyano-pyrazine is reacted with tert-butyl alcohol or isobutylene in the presence of sulfuric acid to obtain the corresponding N-tert-butyl-2-pyrazinecarboxamide and/or 3-cyano-N-tert-butyl-2-pyrazinecarboxamide. Then, thus obtained corresponding N-tert-butyl-2-pyrazinecarboxamide and/or 3-cyano-N-tert-butyl-2-pyrazinecarboxamide are hydrolyzed under an alkaline condition.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05734055uspto-grants-1998_03