Reaction #3708

Reaction equation

3-methoxy-4-nitrobenzoic acid

thionyl chloride

→

3-Methoxy-4-nitrobenzoyl chloride

Solvents

iso-octane

Conditions

Workup

1. 1
   Temperatureis heated
2. 2
   Temperatureto reflux for 2 hours
3. 3
   Otherthe mixture evaporated in vacuo to a solid residue
4. 4
   WashThe residue is washed with iso-octane (2×2 ml)
5. 5
   Otherdried in vacuo
6. 6
   Otherto give 1.08 g of cream

Procedure

A stirred suspension of 1.0 g of 3-methoxy-4-nitrobenzoic acid and 1.40 ml of thionyl chloride is heated to reflux for 2 hours. The mixture is cooled to room temperature, 2 ml of iso-octane added and the mixture evaporated in vacuo to a solid residue. The residue is washed with iso-octane (2×2 ml), dried in vacuo to give 1.08 g of cream colored solid.

Source