Reaction #361604

ord-b9f79328e4874503bf5711493fb7af6b

Reaction equation

O=C1N[C@H](C(=O)O)CS1
L-2-oxothiazolidine-4-carboxylate
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
adenosine triphosphate
→
N[C@@H](CSC(=O)O)C(=O)O
S-carboxyl cysteine

Reactants

O=C1N[C@H](C(=O)O)CS1
L-2-oxothiazolidine-4-carboxylate
Nc1ncnc2c1ncn2[C@@H]1O[C@H](COP(=O)(O)OP(=O)(O)OP(=O)(O)O)[C@@H](O)[C@H]1O
adenosine triphosphate

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

L-2-oxothiazolidine-4-carboxylate, in vivo, is subjected to the action of 5-oxo-L-prolinase in the presence of adenosine triphosphate to produce S-carboxyl cysteine. S-carboxyl cysteine is then decarboxylated to produce cysteine. Cysteine is then metabolized to provide glutathione. See, U.S. Pat. Nos.: 4,355,210; 4,434,158; 4,438,124; 4,665,082; and 4,647,571 the disclosures of which are incorporated herein by reference.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05389657uspto-grants-1995_02