Reaction #360531

ord-9c99d8a7c213412fa9ed3b1ad83c23b2

Reaction equation

$CC/C=C\C/C=C\C/C=C\C/C=C\CCCCC(=O)O$

stearidonic acid

$CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O$

γ-linolenic acid

$CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O$

dihomo-γ-linolenic acid

→

$CCCCC/C=C\C/C=C\CCCCCCCC(=O)O$

Linoleic acid

$CCCCCCCC/C=C\CCCCCCCC(=O)O$

oleic acid

Reactants

$CC/C=C\C/C=C\C/C=C\C/C=C\CCCCC(=O)O$

stearidonic acid

$CCCCC/C=C\C/C=C\C/C=C\CCCCC(=O)O$

γ-linolenic acid

—

(n-3)-eicosatetraenoic acid

$CCCCC/C=C\C/C=C\C/C=C\CCCCCCC(=O)O$

dihomo-γ-linolenic acid

Reagents

None

Solvents

—

PUFA

Conditions

Detailed conditions

See reaction.notes.procedure_details.

Procedure

A number of enzymes, most notably desaturases and elongases, are involved in PUFA biosynthesis (see FIG. 1). For example, an elongase (elo) catalyzes the conversion of γ-linolenic acid (GLA) to dihomo-γ-linolenic acid (DGLA) and of stearidonic acid (C18:4n-3) to (n-3)-eicosatetraenoic acid (C20:4n-3). Linoleic acid (LA, C18:2n-9, 12 or C18:2n-6) is produced from oleic acid (C18:1-Δ9) by a Δ12-desaturase. GLA (C18:3n-6, 9, 12) is produced from linoleic acid by a Δ6-desaturase.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07456270B2uspto-grants-2008_11