Reaction #350014

ord-e308338b065d4a0e872c9134dc241f40

Reaction equation

N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]
2,6-dinitrobenzonitrile
CS
methylmercaptan
CSc1cccc([N+](=O)[O-])c1C#N
2-(methylthio)-6-nitrobenzonitrile
→
CSc1cccc(N)c1C(N)=O
2-Amino-6-(methylthio) benzamide

Reactants

N#Cc1c([N+](=O)[O-])cccc1[N+](=O)[O-]
2,6-dinitrobenzonitrile
CS
methylmercaptan
CSc1cccc([N+](=O)[O-])c1C#N
2-(methylthio)-6-nitrobenzonitrile

Reagents

[Ni]
Raney nickel

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

2-Amino-6-(methylthio) benzamide is prepared by Raney nickel reduction of 2-(methylthio)-6-nitrobenzonitrile which is prepared from 2,6-dinitrobenzonitrile and methylmercaptan following the procedure set forth in Example 56.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US04154961uspto-grants-1979_05