Reaction #347140

Reaction equation

tetrafluorophthalic anhydride

tri-n-octylamine

methanol

→

3,4,5,6-tetrafluorobenzoic acid methyl ester

Yield 92.4%

Conditions

Workup

1. 1
   OtherInto a 100 ml glass reactor equipped with a reflux condenser and a stirrer
2. 2
   OtherThen, the mixture was reacted at 140° C. for 4 hours
3. 3
   OtherAfter completion of the reaction
4. 4
   Otherthe reaction mixture was separated by distillation

Procedure

Into a 100 ml glass reactor equipped with a reflux condenser and a stirrer, 20 g (0.091 mol) of the tetrafluorophthalic anhydride prepared in Example 3 and 32.2 g (0.091 mol) of tri-n-octylamine were charged and 3.5 g (0.109 mol) of methanol was dropwise added thereto. Then, the mixture was reacted at 140° C. for 4 hours. After completion of the reaction, the reaction mixture was separated by distillation to obtain 17.5 g of 3,4,5,6-tetrafluorobenzoic acid methyl ester. The yield was 92.3%.

Source