Reaction #341015

Reaction equation

sodium triacetoxyborohydride

1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea

acetic acid

(4-amino-phenyl)-acetic acid ethyl ester

→

desired product

Yield 30.0%

(4-{[2-(3,3-Dicyclohexyl-ureido)-thiazol-5-ylmethyl]-amino}-phenyl)-acetic acid ethyl ester

Yield 30.0%

Conditions

Workup

1. 1
   OtherPrepared

Procedure

Prepared as described in general procedure (P) using 1,1-dicyclohexyl-3-(5-formyl-thiazol-2-yl)-urea (100 mg. 0.298 mmol), acetic acid (17 μL, 0.29 mmol), (4-amino-phenyl)-acetic acid ethyl ester (14 mg, 0.45 mmol) and sodium triacetoxyborohydride (101 mg, 0.48 mmol) to afford 43 mg (30%) of the desired product after purification.

Source