Reaction #336858

Reaction equation

3a

Ethyl 4-chloro-quinoline-3-carboxylate

2c

Ethyl 6,7-difluoro-4-hydroxy-quinoline-3-carboxylate

→

title compound

Ethyl 4-chloro-6,7-difluoro-quinoline-3-carboxylate

Conditions

Procedure

The title compound was prepared following the procedure described in Step 2 for the synthesis of 3a using 2c instead of 2a. 1H NMR (CDCl3) δ (ppm): 1.47 (3H, t, J=7.08 Hz), 4.56 (2H, q, J=7.08 Hz), 7.72 (1H, d, J=8.79 Hz), 8.39 (1H, d, J=8.78 Hz), 9.23 (1H, s). m/z 271.6/273.6 (M+/M+2). m/z 272.6 (MH+).

Source