Reaction #336857

Reaction equation

2a

Ethyl 4-hydroxy-quinoline-3-carboxylate

3,4-difluoroaniline

→

title compound

Ethyl 6,7-difluoro-4-hydroxy-quinoline-3-carboxylate

Conditions

Procedure

The title compound was prepared following the procedure described Step 1 for the synthesis of 2a using 3,4-difluoroaniline instead of aniline. 1H NMR (DMSO-d6) δ (ppm): 1.15 (3H, t, J=7.08 Hz), 4.1 (2H, q, J=7.08 Hz), 7.61 (1H, dd, J=8.30, 2.93 Hz), 7.68 (1H, dd, J=4.63, 9.03 Hz), 7.80 (1H, dd, J=9.27, 2.93 Hz), 8.56 (1H, s). m/z 254.3 (MH+).

Source