Reaction #336850
ord-14d96c75fdcb4a85a34f10dc3a1a4f64
Reaction equation
ethyl 4-chloro-quinoline-3-carboxylate
Ethyl 4-chloro-quinoline-3-carboxylate
triethylamine
phenyl hydrazine
→
crude product
2-Phenyl-2,5-dihydro-pyrazolo-(4,3-c) quinolin-3-one
Reactants
Reagents
None
Solvents
Conditions
Detailed conditions
See reaction.notes.procedure_details.
Procedure
A suspension of ethyl 4-chloro-quinoline-3-carboxylate (3a) (2.35 g, 0.01 M) in 20 mL of o-xylene was refluxed with triethylamine (2.0 mL, 0.02 M) and phenyl hydrazine (2.89 g, 0.02 M) overnight. The crude product was obtained by filtration followed by washing the solid with cold methanol.