Reaction #336849
ord-aca77ffdeac44d3e983f530c8670cda2
Reaction equation
2-phenylaminomethylene-malonic acid diethyl ester
→
ethyl 4-hydroxy-quinoline-3-carboxylate
Ethyl 4-hydroxy-quinoline-3-carboxylate
Reagents
None
Solvents
Conditions
Temperature
80°CELSIUS
Detailed conditions
See reaction.notes.procedure_details.
Workup
- 1Filtrationsolid was collected by filtration
- 2Washwashed with hexane
Procedure
The 2-phenylaminomethylene-malonic acid diethyl ester was refluxed in Dowtherm® for 15 min to 2 h. The reaction mixture was cooled to 80° C. and solid was collected by filtration and washed with hexane to yield crude ethyl 4-hydroxy-quinoline-3-carboxylate 2a which was used in next step without further purification.