Reaction #335657

Reaction equation

ester

6,7-difluoro-4-hydroxy-3-quinolinecarboxylic acid ethyl ester

sodium hydroxide

acetic acid

→

1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid

Solvents

hydrochloric acid

Conditions

Workup

1. 1
   Temperaturecooled
2. 2
   OtherThe solid was collected
3. 3
   Washwashed with water, methanol, ether
4. 4
   Otherdried

Procedure

A 4.1 g portion of the above ester in 50 ml of 37% hydrochloric acid was refluxed overnight, then cooled, basified with sodium hydroxide and then acidified with glacial acetic acid. The solid was collected, washed with water, methanol, ether and dried, giving 3.6 g of 1-ethyl-6,7-difluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid.

Source