Reaction #331481

Reaction equation

compound

4,5-dibromo-1,2-cyclohexanediol

2,2-dimethoxypropane

p-toluenesulfonic acid

→

5,6-dibromo-2,2-dimethylhexahydro-1,3-benzodioxol

Conditions

Workup

1. 1
   Filtrationthe mixture was filtrated through activated alumina
2. 2
   Concentrationthe filtrate was concentrated under reduced pressure

Procedure

The compound obtained in Step (10) (20.6 g, 75.62 mmol) was placed in a reaction vessel, and air in the vessel was replaced with nitrogen. 2,2-dimethoxypropane (12.92 ml) and p-toluenesulfonic acid (0.9 g) were added to the vessel, and the mixture was stirred for 3 hours. After the completion of the reaction had been confirmed, the mixture was filtrated through activated alumina, and the filtrate was concentrated under reduced pressure, whereby 5,6-dibromo-2,2-dimethylhexahydro-1,3-benzodioxol was obtained (17.1 g, 72%).

Source