Reaction #327081

Reaction equation

2-fluoro-4-hydroxybenzoic acid

sulfuric acid

methanol

→

title compound

Yield 94.0%

methyl 2-fluoro-4-hydroxybenzoate

Yield 94.0%

Conditions

Workup

1. 1
   ConcentrationThe reaction solution was concentrated
2. 2
   Washthe resulting colorless crystals were washed with water
3. 3
   Otherdried

Procedure

A solution of 2-fluoro-4-hydroxybenzoic acid (50.0 g) and concentrated sulfuric acid (10 mL) in methanol (700 mL) was stirred with heating at 90° C. for 16 hr. The reaction solution was concentrated, and the resulting colorless crystals were washed with water, and dried to give the title compound (51 g, yield 94%) as colorless crystals.

Source