Reaction #325030

ord-18fafd85b6f3414689c4ce92953b4a23

Reaction equation

Cc1ccc(S(=O)(=O)O)cc1
p-toluenesulfonic acid
CCOC(=O)C#CCCOC1CCCCO1
5-(tetrahydro-pyran-2-yloxy)-pent-2-ynoic acid ethyl ester
→
CCOC(=O)C#CCCO
title compound
CCOC(=O)C#CCCO
5-Hydroxy-pent-2-ynoic acid ethyl ester

Reactants

Cc1ccc(S(=O)(=O)O)cc1
p-toluenesulfonic acid
CCOC(=O)C#CCCOC1CCCCO1
5-(tetrahydro-pyran-2-yloxy)-pent-2-ynoic acid ethyl ester

Reagents

None

Solvents

CCO
ethanol

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

The title compound was prepared from 5-(tetrahydro-pyran-2-yloxy)-pent-2-ynoic acid ethyl ester employing p-toluenesulfonic acid in ethanol.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08642603B2uspto-grants-2014_02