Reaction #324437

ord-ea259660f80349a780f6e0ca244905f9

Reaction equation

OCc1cccc(C(F)(F)F)n1
title compound
OCc1cccc(C(F)(F)F)n1
(6-Trifluoromethyl-pyridin-2-yl)-methanol
CC(C)(C)OC(=O)N1CC(Oc2cc(Cl)ccc2O)C1
3-(5-Chloro-2-hydroxy-phenoxy)-azetidine-1-carboxylic acid tert-butyl ester
→
CC(C)(C)OC(=O)N1CC(Oc2cc(Cl)ccc2OCc2cccc(C(F)(F)F)n2)C1
3-[5-Chloro-2-(6-trifluoromethyl-pyridin-2-ylmethoxy)-phenoxy]-azetidine-1-carboxylic acid tert-butyl ester

Reactants

OCc1cccc(C(F)(F)F)n1
title compound
OCc1cccc(C(F)(F)F)n1
(6-Trifluoromethyl-pyridin-2-yl)-methanol
CC(C)(C)OC(=O)N1CC(Oc2cc(Cl)ccc2O)C1
3-(5-Chloro-2-hydroxy-phenoxy)-azetidine-1-carboxylic acid tert-butyl ester

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared from the title compound of Step A and 3-(5-Chloro-2-hydroxy-phenoxy)-azetidine-1-carboxylic acid tert-butyl ester using general procedure 7.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08642583B2uspto-grants-2014_02