Reaction #324361

ord-cc18d6845501455995a9f42bb0d6eea0

Reaction equation

Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1.O=C(O)C(O)C(O)C(=O)O
Tolterodine tartrate
→
Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1
Tolterodin

Reactants

Cc1ccc(O)c([C@H](CCN(C(C)C)C(C)C)c2ccccc2)c1.O=C(O)C(O)C(O)C(=O)O
Tolterodine tartrate
—
cellulose
—
ethylcellulose

Reagents

None

Solvents

O
water

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherDry pellet cores
  2. 2
    workup.DISSOLUTIONWithin first hour almost 50% dissolves, however between 7 and 16 hours
  3. 3
    workup.DISSOLUTIONless dissolves

Procedure

Tolterodine tartrate, microcrystalline cellulose and part of ethylcellulose are blended with small amount of water into homogeneous blend from which pellet cores are made by extrusion and spheronization. Dry pellet cores are coated with the coating dispersion of Example 8. Within first hour almost 50% dissolves, however between 7 and 16 hours less dissolves as compared to Example 2.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US08642078B2uspto-grants-2014_02