Reaction #321640

Reaction equation

2-ethylthiophene-5-boronic acid

N-(5-bromothiophene-2-sulfonyl)pyrrole

→

N-[5-(5-ethyl-2-thienyl)thiophene-2-sulfonyl]pyrrole

Conditions

Workup

1. 1
   OtherPurification by column chromatography

Procedure

N-[5-(5-ethyl-2-thienyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C from 2-ethylthiophene-5-boronic acid (411 mg, 2.64 mmol) and N-(5-bromothiophene-2-sulfonyl)pyrrole (700 mg, 2.39 mmol). Purification by column chromatography using 2% ethyl acetate/hexanes gave 6.30 mg of the pure product as a dark brown solid (90% yield).

Source