Reaction #321628

Reaction equation

4-methyl-phenylboronic acid

N-(5-bromothiophenesulfonyl)pyrrole

→

N-[5-(4-methylphenyl)thiophene-2-sulfonyl]pyrrole

Conditions

Workup

1. 1
   OtherN-[5-(4-methylphenyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner
2. 2
   OtherPurification by column chromatography

Procedure

N-[5-(4-methylphenyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C using 4-methyl-phenylboronic acid and N-(5-bromothiophenesulfonyl)pyrrole. Purification by column chromatography using 2% ethyl acetate/hexanes gave N-[5-(4-methylphenyl)thiophene-2-sulfonyl]pyrrole as a pale yellow solid in 77% yield.

Source