Reaction #321554

ord-f4509aa58e704c21a3b7b244031cc66e

Reaction equation

COc1cccc(B(O)O)c1
3-methoxyphenylboronic acid
O=S(=O)(c1ccc(Br)s1)n1cccc1
N-(5-bromothiophene-2-sulfonyl)pyrrole
→
COc1cccc(-c2ccc(S(=O)(=O)n3cccc3)s2)c1
N-[5-(3-methoxyphenyl)thiophene-2-sulfonyl]pyrrole
Yield 93.0%

Reactants

COc1cccc(B(O)O)c1
3-methoxyphenylboronic acid
O=S(=O)(c1ccc(Br)s1)n1cccc1
N-(5-bromothiophene-2-sulfonyl)pyrrole

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherThis was purified by recrystallization

Procedure

N-[5-(3-methoxyphenyl)thiophene-2-sulfonyl]pyrrole was prepared in the same manner as described in Example 32C from 3-methoxyphenylboronic acid and N-(5-bromothiophene-2-sulfonyl)pyrrole in 93% yield. This was purified by recrystallization using hexane/ethyl acetate as solvent.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05594021uspto-grants-1997_01