Reaction #321502

ord-3cfad4bb7beb4ac99de8b03712869ff0

Reaction equation

CCc1ccc(B(O)O)cc1
4-ethylphenylboronic acid
O=S(=O)(c1ccc(Br)s1)n1cccc1
N-(5-bromothiophenesulfonyl)pyrrole
→
CCc1ccc(-c2ccc(S(=O)(=O)n3cccc3)s2)cc1
N-[5-(4-ethylphenyl)thiophene-2-sulfonyl]pyrrole
Yield 81.0%

Reactants

CCc1ccc(B(O)O)cc1
4-ethylphenylboronic acid
O=S(=O)(c1ccc(Br)s1)n1cccc1
N-(5-bromothiophenesulfonyl)pyrrole

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Workup

  1. 1
    OtherPurification by column chromatography

Procedure

N-[5-(4-ethylphenyl)thiophene-2-sulfonyl]pyrrole was prepared, in the same manner as described in Example 32C, from 4-ethylphenylboronic acid and N-(5-bromothiophenesulfonyl)pyrrole. Purification by column chromatography using 10% ethyl acetate/hexanes gave the pure sulfonamide as a tan solid in 81% yield.

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US05594021uspto-grants-1997_01