Reaction #312739

ord-9b593471494d4edbb3aaca3a3fa8670b

Reaction equation

CC(C)N(C(=O)c1ccc(C(F)(F)F)cn1)C(C)C
5-Trifluoromethyl-pyridine-2-carboxylic acid diisopropylamide
CON(C)C(C)=O
N-methoxy-N-methylacetamide
→
CC(=O)c1cc(C(F)(F)F)cnc1C(=O)N(C(C)C)C(C)C
3-Acetyl-5-trifluoromethyl-pyridine-2-carboxylic acid diisopropylamide

Reactants

CC(C)N(C(=O)c1ccc(C(F)(F)F)cn1)C(C)C
5-Trifluoromethyl-pyridine-2-carboxylic acid diisopropylamide
CON(C)C(C)=O
N-methoxy-N-methylacetamide

Reagents

None

Conditions

Detailed conditions
See reaction.notes.procedure_details.

Procedure

Prepared in analogy to Example A17(b) from 5-Trifluoromethyl-pyridine-2-carboxylic acid diisopropylamide (CAS: 765298-31-5) and N-methoxy-N-methylacetamide instead of dimethylformamide. Orange solid. MS (m/e): 317.1 ([M+H]+, 100%)

Source

DOI: 10.6084/m9.figshare.5104873.v1Patent: US07557114B2uspto-grants-2009_07