Reaction #312614

Reaction equation

5-aminoindole

bis(2-chloroethyl)amine hydrochloride

triethylamine

→

5-piperazin-1-yl-1H-indole

Yield 100.0%

Solvents

butanol

Conditions

Workup

1. 1
   Concentrationconcentrated in vacuo

Procedure

A solution of 5-aminoindole (6.23 g, 47 mmol), bis(2-chloroethyl)amine hydrochloride (16.8 g, 96 mmol) and triethylamine (19 mL, 141 mmol) in butanol is heated at 100° C. for 8 hours, cooled to room temperature and concentrated in vacuo to give 9.46 g of 5-piperazin-1-yl-1H-indole.

Source